Joint Linkage and Linkage Disequilibrium Mapping in Natural Populations
نویسندگان
چکیده
منابع مشابه
Joint linkage and linkage disequilibrium mapping in natural populations.
A new strategy for studying the genome structure and organization of natural populations is proposed on the basis of a combined analysis of linkage and linkage disequilibrium using known polymorphic markers. This strategy exploits a random sample drawn from a panmictic natural population and the open-pollinated progeny of the sample. It is established on the principle of gene transmission from ...
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Linkage analysis and allelic association (also referred to as linkage disequilibrium) studies are two major approaches for mapping genes that control simple or complex traits in plants, animals, and humans. But these two approaches have limited utility when used alone, because they use only part of the information that is available for a mapping population. More recently, a new mapping strategy...
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1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...
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ژورنال
عنوان ژورنال: Genetics
سال: 2001
ISSN: 1943-2631
DOI: 10.1093/genetics/157.2.899